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Get 24-hour relief from frequent heartburn with Nexium 24HR Capsules. Nexium 24HR Capsules work by blocking acid directly at the source, giving you 24 hours of protection (4) from frequent heartburn. Just one Capsule a day provides all-day, all-night protection (4) from frequent heartburn. Nexium 24HR is the #1 Selling OTC frequent heartburn brand.